:: Volume 18, Issue 56 (6-2017) ::
Zanko J Med Sci 2017, 18(56): 12-20 Back to browse issues page
Arvin Rahmanpor , Mehran Nasiri , Mohammad reza Farahpor
Abstract:   (553 Views)


Introduction: Hypoxia brings about detrimental changes in the correct structure and function of the brain. Accordingly, any medication (or compound) which result in the stability and strength of the brain upon hypoxia or ischemia, would be highly remarkable medically.

Target: Anti-hypoxia compounds are effective in treatment and prevention of this problematic. Hypoxia brings significant changes to the activity of various enzymes in body, hence discovering medical solutions which decrease the death rate seems necessary.

Analysis method: This study analyzes anti-hypoxia activity with a two-extract concentration through three standard methods in hypoxia mice. In this study 80 male mice are divided into three groups.

Results: In the anti-hypoxia of blood analysis, an intraperitoneal injection through NaNO2 in the control group, result in the death rate of 8.013±0.827 during the study. Comparing to the control group, both groups of Vicia hirsuta methanol extract had significant impacts (p<0.05). In hypoxic blood circulation, the intraperitoneal injection of NaF yields significant results. The compound was more effective at a 100 mg/kg dosage.Extract at a dose of 50 mg/kg increased the survival (p<0.05). In the hypoxic asphyxia, placing the animals in a sealed glass container brings on noticeable results. At a dosage of 50 mg/kg of methanol extract of Vicia hirsuta and at a dosage of 100 mg/kg  (p<0.05). mice were kept alive, and comparing to the control group, these results were revealing and remarkable.

Conclusion: according to the results obtained can be used to Vicia hirsute extract favorable effects of anti-hypoxia

Keywords: Anti-hypoxia, Vicia hirsute, Antioxidants, Mice
Full-Text [PDF 677 kb]   (253 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/12/7 | Accepted: 2016/12/26 | Published: 2017/06/21

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Volume 18, Issue 56 (6-2017) Back to browse issues page