Volume 15, Issue 46 (12-2014)
Zanko J Med Sci 2014, 15(46): 8-18 |
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Charkhpour M, Parvizpur A, Namjo Z, Moradi S, Hassanzadeh K. Evaluation the effect of central A2a receptor inhibition on morphine withdrawal symptoms in rats. Zanko J Med Sci 2014; 15 (46) :8-18
URL: http://zanko.muk.ac.ir/article-1-24-en.html
URL: http://zanko.muk.ac.ir/article-1-24-en.html
Abstract: (3325 Views)
Abstract
Background and Aim: The aim of this study was to evaluate the effect of intracerebroventricular (icv) administration of antagonist of A2a receptore on morphine withdrawal syndrome in male rat.
Method: Male wistar rats (200-250 gr) were selected randomly and divided into six groups (n=8). Morphine was administered twice a day for nine days (day 1: 5mg/kg/12h, day 2,3: 10mg/kg/12h, day 4,5: 15 mg/kg/12h, day 6,7: 20mg/kg/12h, day 8,9: 25 mg/kg/12h).
SCH-58261)40, 80, 160µg/5µl/Rat) injected interacerebroventricular on 9th day, 30 minute after the last dose of morphine. Tirtheen minutes later, naloxone (4mg/kg, ip) injected and the withdrawal signs (Rearing, Genital Grooming, Abdomen Writhing, Teeth Chattering and Wet Dog Shake) were recorded for 60 minutes.
Result: Results showed that chronic morphine administration for nine days induced morphine dependency and naloxone injection percipitated withdrawal symptoms in dependent rats. Also the results indicated that intracerebroventricular administration of A2a receptore antagonist (SCH-58261) reduced all morphine-induced withdrawal symptoms.
Conclusion: In conclusion we found that central injection of SCH-58261 as an A2a receptore antagonist decreased morphine withdrawal symptoms in rats.
Type of Study: Research |
Subject:
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Received: 2014/10/8 | Accepted: 2014/10/26 | ePublished: 2014/12/6
Received: 2014/10/8 | Accepted: 2014/10/26 | ePublished: 2014/12/6
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