Background and Aim: Prenatal depression can have significant complications for both the mother and the infant, but due to the lack of diagnosis and treatment, depressed pregnant women often suffer from many problems. Mindfulness treatment improves psychological well-being, reduces the risk of recurrence of depression and also reduces the symptoms of stress and depression. So the purpose of this study was to determine the effect of mindfulness on depression in pregnant women in Sanandaj.
Material and Method: The research method was quasi-experimental with pretest-posttest control group design. Out of 500 pregnant women referred to Sanandaj clinics and maternity ward of Baysat Hospital, 250 had high depression score. 30 women were selected and randomly assigned to intervention and control groups.  Independent and paired t-test and spss v.22 software were used to compare quantitative variables between the two groups. Two members of the control and the experimental group were lost to follow up and 13 women were assigned to each group.
Results: The results showed that the mean age of the mothers was 29.54±5.15 years and the mean age of their marriage was 24.38±5.34 years. There was no significant difference in terms of demographic characteristics (age, level of education and occupation) between the two groups (p> 0.05). The two groups were similar in terms of depression before the intervention, but the difference was significant after the intervention (p <0.05).
Conclusion: The results of this study showed a significant effect of mindfulness-based stress reduction training on depression in pregnant women.

Keywords: Depression, Pregnant Women, Mindfulness

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