TY - JOUR T1 - The Effect of High Intensity Interval Training on Serum Level of Orexin A and Insulin Resistance Index in Type 2 Diabetic Male Rats TT - اثر تمرین تناوبی با شدت بالا (HIIT) بر سطح سرمی اورکسین A و شاخص مقاومت به انسولین موش‌‌های صحرایی نر دیابتی نوع 2 JF - muk-zanko JO - muk-zanko VL - 19 IS - 63 UR - http://zanko.muk.ac.ir/article-1-400-en.html Y1 - 2019 SP - 31 EP - 41 KW - Diabetes mellitus type 2 KW - Oroxin A KW - Insulin resistance index KW - HIIT training. N2 - Background and Aim: Evidence suggests that orexin regulates the consumption of food, glucose metabolism, and insulin secretion. Orexin may play a role in the pathogenesis of type 2 diabetes, but its role in affecting physical activity is unclear. The purpose of this study was to investigate the effect of 10-week high-intensity interval training (HIIT) on serum level of orexin A and insulin resistance index in type 2 diabetic rats. Material and Method: In this experimental study, 36 Wistar rats aged 8 weeks in a weighing range of 261±43 grams were randomly divided into three groups (healthy control, diabetic control, and diabetic with HIIT). The diabetic with HIIT group performed a regular HIIT training with a treadmill for one week after induction of diabetes. Twenty four hours after the last training session, blood serum of the rats were collected to evaluate the serum levels of orexin A and insulin. Data were analyzed using one way ANOVA and Tukey post hoc test in SPSS19 software. Results: 10 weeks of HIIT resulted in a significant decrease in fasting blood glucose (P = 0.000), insulin (P = 0.001), insulin resistance index (P = 0.000), and a significant increase in serum levels of orexin A (P = 0.039) in the HIIT group compared to the diabetic control group. Conclusion: High intensity interval training (HIIT) seems to reduce insulin resistance in type 2 diabetic rats by increasing levels of orexin A levels. M3 ER -