Background and Aim: Prudent and rational use of antimicrobial is possible by forming local, national and global wide antibiogram. Aim of this study was to determination of antibiotic-resistant prevalence Klebsiella pneumonia isolated from patients in Besat Hospital, Sanandaj, Iran.

 Materials and Methods: This cross-sectional descriptive study to evaluate the prevalence of antibiotic resistance of Klebsiella pneumonia was performed during 2013 and 2014 in Besat Hospital. After the identification of Klebsiella pneumonia isolates by microbiological method, antibiotic susceptibility testing was performed by disk diffusion according to CLSI standards. For data analysis software Excel 2013 and SPSS v22 was used.

Results: Through the total of 1563 Specimens, in which 67 Klebsiella pneumonia (4.28%) was isolated. the highest percent of Klebsiella related to the ICU ward (28.36%) and women ward (26.86%) were isolated. Most strains of Klebsiella pneumonia isolated from urine samples (67.16%) and the lowest it from blood samples (4.47%), respectively. The highest sensitivity to imipenem (73.81%) and gentamicin (70.91%) and the highest resistance to Trimetoprim-sulfamethoxazole (53.73%) and ceftriaxone (49.25%) were seen.

Conclusion: The results showed an increase in strains of Klebsiella pneumonia to antibiotics trimethoprim- sulfamethoxazole and ceftriaxone, which may cause irregular use of this antibiotic. It is recommended that the unnecessary use of antibiotics must be avoided.