Volume 18, Issue 59 (1-2018)
Zanko J Med Sci 2018, 18(59): 16-27 |
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Zargaran M. The study of cellular proliferation in oral squamous cell carcinoma: an immunohistochemical study by Ki67 marker. Zanko J Med Sci 2018; 18 (59) :16-27
URL: http://zanko.muk.ac.ir/article-1-220-en.html
URL: http://zanko.muk.ac.ir/article-1-220-en.html
Abstract: (3418 Views)
Abstract
Background and Aim: Oral squamous cell carcinoma (OSCC) develops through a series of precancerous stages manifested at the microscopic level as epithelial dysplasia and Ki-67 gene may play an important role in this course. The aim of this study was to comparative investigation of Ki67 expression in oral epithelial dysplasia and OSCC by immunohistochemistery technique .
Materials and methods: Ki67 expression was evaluated in paraffin blocks of 15epithelial hyperplasia with no dysplasia (A group), 15 epithelial dysplasia (B group) including 7 mild epithelial dysplasia (B1subgroup) and 8 sever epithelial dysplasia (B2 subgroup), 15 OSCC (C group) including 7 well differentiated OSCC (C1 subgroup) and 8 poorly diffrentiated OSCC(C2 subgroup).
Results: There was a significant difference in Ki67 expression based on quantitative and smiquantitative analysis between the three groups and Ki67-positive cells were significantly higher in C group than B group. A positive significant difference was observed between Ki67-positive cells and increasing grade of dysplasia ( P<0/001 ).However, Ki67 expression was not significant different between histopathological grades of OSCC ( p=0/064) .
Conclusion: Ki-67 may represent a significant marker to recognize evolution of precancerous diseases in the oral cavity, a reliable marker to improve identification of the degree of dysplasia and for the prediction of malignant change in these lesions.
Background and Aim: Oral squamous cell carcinoma (OSCC) develops through a series of precancerous stages manifested at the microscopic level as epithelial dysplasia and Ki-67 gene may play an important role in this course. The aim of this study was to comparative investigation of Ki67 expression in oral epithelial dysplasia and OSCC by immunohistochemistery technique .
Materials and methods: Ki67 expression was evaluated in paraffin blocks of 15epithelial hyperplasia with no dysplasia (A group), 15 epithelial dysplasia (B group) including 7 mild epithelial dysplasia (B1subgroup) and 8 sever epithelial dysplasia (B2 subgroup), 15 OSCC (C group) including 7 well differentiated OSCC (C1 subgroup) and 8 poorly diffrentiated OSCC(C2 subgroup).
Results: There was a significant difference in Ki67 expression based on quantitative and smiquantitative analysis between the three groups and Ki67-positive cells were significantly higher in C group than B group. A positive significant difference was observed between Ki67-positive cells and increasing grade of dysplasia ( P<0/001 ).However, Ki67 expression was not significant different between histopathological grades of OSCC ( p=0/064) .
Conclusion: Ki-67 may represent a significant marker to recognize evolution of precancerous diseases in the oral cavity, a reliable marker to improve identification of the degree of dysplasia and for the prediction of malignant change in these lesions.
Type of Study: Research |
Subject:
Special
Received: 2017/09/3 | Accepted: 2017/10/19 | ePublished: 2018/01/19
Received: 2017/09/3 | Accepted: 2017/10/19 | ePublished: 2018/01/19
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