Volume 15, Issue 46 (12-2014)                   Zanko J Med Sci 2014, 15(46): 49-58 | Back to browse issues page

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Faraji K, Neamatzade S, Saboori H. Radiation effect on the number of circulating blood cells in patients receiving radiation therapy in Tohid hospital of Sanandaj in 2014. Zanko J Med Sci 2014; 15 (46) :49-58
URL: http://zanko.muk.ac.ir/article-1-28-en.html
Abstract:   (8334 Views)
Background and Aim: Bone marrow suppression as a serious complication of radiotherapy induces leucopenia or neutropenia that results to hospitalization and antibiotic therapy. There is considerable controversy in scientific literature regarding the need to monitor the complete blood count of patients undergoing radiation therapy. While some advocate weekly examination of the peripheral blood, others deem it unnecessary. Since reduction in the number of blood cells has considerable effect on the treatment outcome, this study evaluates the effect of radiation therapy on the number of blood cells.
Methods and Materials: This study designed as a retrospective descriptive study of pre- and post-treatment evaluation. The mean ages of patients was 56 years, and with a mean dose of 52 Gy in 28 fractions were treated. 170 patients who had received radiation therapy, evaluated by comparing the mean count of the circulating blood cells before, during and after therapy. For this purpose the average of hemoglobin, Platelets, Lymphocytes, Neutrophils and white blood cell count were recorded and analyzed. 
Results: there was a significant relationship Between age and the reduction in white blood cells, hemoglobin, lymphocytes, neutrophils and platelets (p<0/05). also, there was a significant relationship between white blood cells with total dose and number of fractions ,platelets and hemoglobin with duration of treatment and neutrophils with total dose ,number of fractions and duration of treatment(p<0/05). Reduction of blood cells and the need for blood transfusions and injections of PDG was higher in patients with a mean high age. Decline in WBC in the cases had direct relation with total dose and number of fractions. Reduction of hemoglobin and platelet count was more closely related to the duration of treatment and PMN rate in these patients was associated with all of the above.concurrent or prior chemotherapy and gender had no significant relationship with changes in blood cells. 
Conclusion: It can be concluded that radiotherapy leads to a reduction in the amount of blood cells .this reduction depends on some factors such as age, duration of treatment, the number of fractions and the total dose.
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Type of Study: Research | Subject: Special
Received: 2014/10/24 | Accepted: 2014/11/17 | ePublished: 2014/12/6

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