Volume 19, Issue 63 (1-2019)                   Zanko J Med Sci 2019, 19(63): 31-41 | Back to browse issues page

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parastesh M, saremi A. The Effect of High Intensity Interval Training on Serum Level of Orexin A and Insulin Resistance Index in Type 2 Diabetic Male Rats. Zanko J Med Sci 2019; 19 (63) :31-41
URL: http://zanko.muk.ac.ir/article-1-400-en.html
Arak univercity
Abstract:   (2131 Views)
Background and Aim: Evidence suggests that orexin regulates the consumption of food, glucose metabolism, and insulin secretion. Orexin may play a role in the pathogenesis of type 2 diabetes, but its role in affecting physical activity is unclear. The purpose of this study was to investigate the effect of 10-week high-intensity interval training (HIIT) on serum level of orexin A and insulin resistance index in type 2 diabetic rats.
Material and Method:
In this experimental study, 36 Wistar rats aged 8 weeks in a weighing range of 261±43 grams were randomly divided into three groups (healthy control, diabetic control, and diabetic with HIIT). The diabetic with HIIT group performed a regular HIIT training with a treadmill for one week after induction of diabetes.
Twenty four hours after the last training session, blood serum of the rats were collected to evaluate the serum levels of orexin A and insulin. Data were analyzed using one way ANOVA and Tukey post hoc test in SPSS19 software.
Results: 10 weeks of HIIT resulted in a significant decrease in fasting blood glucose (P = 0.000), insulin (P = 0.001), insulin resistance index (P = 0.000), and a significant increase in serum levels of orexin A (P = 0.039) in the HIIT group compared to the diabetic control group.
Conclusion: High intensity interval training (HIIT) seems to reduce insulin resistance in type 2 diabetic rats by increasing levels of orexin A levels.

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Type of Study: Research | Subject: Special
Received: 2018/05/4 | Accepted: 2018/06/5 | ePublished: 2019/01/15

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