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:: Volume 15, Number 47 (2-2015) ::
Zanko J Med Sci 2015, 15(47): 52-57 Back to browse issues page
A 2 months old infant with severe combined immunodeficiency
rasool nasiri kalmarzy, abdollah sedaghat, banafshe sedaghat, gholamreza irandoost, maryam sayfmanesh, nima fattahi
student kurdistan university of medical sciences
Abstract:   (806 Views)
Background: Severe combined immunodeficiency (SCID) is a primary Immunodeficiency syndrome which is created by diverse genetic mutations. It will lead to the absence of all adaptive immune functions in all affected patients and a lack of Natural Killer cells in some cases. Affected infants will almost always die before their second birthday, due to serious and intractable infections. The reasons of these infections are the opportunistic microorganisms which cause mild or self-limited diseases in immunocompetent hosts. If population-based newborn screening programs has not been established in a community (which is the case in many parts of the world), the best test for early diagnosis is the determination of Absolute Lymphocyte Count (ALC) in peripheral blood. These patients are uniformly lymphopenic because normally T-cells constitute 70% of peripheral blood lymphocytes and patients lack or have extremely low number of them. Case report: We present a two month-old male infant with chronic diarrhea, failure to thrive and lymphopenia in which the result of examinations showed a rare type of immunodeficiency in which flow-cytometry of peripheral blood was consistent with T – B+ NK- variant of SCID
Keywords: Severe combined Immunodeficiency, Absolute lymphocyte count, Newborn Screening, flow-cytometry
Full-Text [PDF 370 kb]   (231 Downloads)    
Type of Study: case report | Subject: Special
Received: 2015/03/9 | Accepted: 2015/03/26 | Published: 2015/03/29
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nasiri kalmarzy R, sedaghat A, sedaghat B, irandoost G, sayfmanesh M, fattahi N. A 2 months old infant with severe combined immunodeficiency. Zanko J Med Sci. 2015; 15 (47) :52-57
URL: http://zanko.muk.ac.ir/article-1-62-en.html
Volume 15, Number 47 (2-2015) Back to browse issues page
مجله علوم پزشکی زانکو Zanko Journal of Medical Sciences
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